In Germany, the boy Elias checks in the luggage of his mother Nadja in the overnight flight Translatlantic 473 to New York. The Muslin passenger Farid helps Elias with the luggage and befriends him. Elias tells Farid that his mother has a serious blood disease and is traveling to New York to be treated by an American doctor. They embark on the plane and once in the air, a group of terrorists led by Berg and including the copilot Bastian Buchner and the flight attendant Eightball hijack the plane. Eightball is a psychopath, and the terrorists kill the pilot and the three security guards on board. They order the passengers to stay sit and bring Farid and two other Muslin passengers to read a message to the authorities, as if they were the hijackers. However, their true intention is to crash the London stock market that is heat and raise lots of money. Elias sees the airplane drawings and decides to run to the cargo compartment, despite the warning of Nadja, and she is shot by Eightball trying to protect her son. While dying, she recalls how she contracted the mysterious illness and, out of the blue, she becomes an awful creature. Now the terrorists have a serious menace to their plan.